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574714 Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem

Syk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).

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Sinónimos: 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

Primary Target: Syk
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574714
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CAS #Empirical Formula
732983-37-8C₂₀H₁₈N₆O₃ • HCl • H₂O

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      Description
      OverviewA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
      Catalogue Number574714
      Brand Family Calbiochem®
      Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
      References
      ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.
      Product Information
      CAS number732983-37-8
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₀H₁₈N₆O₃ • HCl • H₂O
      Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSyk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).
      Biological Information
      Primary TargetSyk
      Primary Target IC<sub>50</sub>10 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      574714-2MG 04055977189698