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572660 SU11652 - CAS 326914-10-7 - Calbiochem

A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor.

SU11652 - CAS 326914-10-7 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII

Primary Target: PDGFRB
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Descripción

Tabla espec. clave

CAS #Empirical Formula
326914-10-7C₂₂H₂₇ClN₄O₂

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572660-500UG
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      Description
      OverviewA cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 = ~ 10-500 nM) over EGFR (IC50 >20 µM). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.
      Catalogue Number572660
      Brand Family Calbiochem®
      Synonyms5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
      References
      ReferencesHeryanto, B., et al. 2003. Reproduction 125, 334.
      Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
      Liao, A.T., et al. 2002. Blood 100, 585.
      Product Information
      CAS number326914-10-7
      ATP CompetitiveY
      FormOrange powder
      Hill FormulaC₂₂H₂₇ClN₄O₂
      Chemical formulaC₂₂H₂₇ClN₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPDGFRB
      Primary Target IC<sub>50</sub>3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      572660-500UG 04055977266320