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525276 Phosphoramidon, Disodium Salt - Calbiochem

Inhibits some metalloendopeptidases.

Phosphoramidon, Disodium Salt - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na

Primary Target: thermolysin
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525276
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₃H₃₂N₃O₁₀P · 2Na

Precios y disponibilidad

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525276-5MG
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      Description
      OverviewInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
      Effective concentration: 1-10 µM.
      Catalogue Number525276
      Brand Family Calbiochem®
      SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
      References
      ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
      Howell, S., et al. 1993. Biochem. J. 290, 159.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₃H₃₂N₃O₁₀P · 2Na
      Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetthermolysin
      Primary Target IC<sub>50</sub>4.6 µM against the conversion of big endothelin-1 to endothelin
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      525276-5MG 04055977270648

      Documentation

      Phosphoramidon, Disodium Salt - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Phosphoramidon, Disodium Salt - Calbiochem Certificados de análisis

      CargoNúmero de lote
      525276

      Referencias bibliográficas

      Visión general referencias
      Balwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
      Howell, S., et al. 1993. Biochem. J. 290, 159.

      Citas

      Título
    • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      SynonymsN-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan, 2Na
      DescriptionInhibits some metalloendopeptidases. Highly specific inhibitor of thermolysin. Inhibits the conversion of big endothelin-1 to endothelin (IC50 = 4.6 µM).
      FormWhite lyophilized solid
      Chemical formulaC₂₃H₃₂N₃O₁₀P · 2Na
      PuritySingle spot by TLC
      SolubilityDMSO (10 mg/ml), methanol, or H₂O
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesBalwierczxak, J.L., et al. 1995. Biochem. Pharmacol. 49, 291.
      Howell, S., et al. 1993. Biochem. J. 290, 159.
      Citation
    • Peter Oishi, et al. (2006) Nitric Oxide-Endothelin-1 Interactions After Surgically Induced Acute Increases in Pulmonary Blood Flow in the Intact Lamb. American Journal of Physiology Heart and Circulatory Physiology 290, H1922-1932.
    • Anthony R. White, et al. (2006) Degradation of the alzheimer disease amyloid -peptide by metal-dependent up-regulation of metalloprotease activity. journal of Biological Chemistry 281, 17670-17680.
      		•