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520222 PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem

PPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: Thrombin
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520222
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
82188-90-7C₂₁H₃₃N₆O₃•2HCl

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
520222-25MG
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      520222-5MG
      Comprobando disponibilidad...
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 5 mg
          Recuperando precio...
          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
          Maximum Quantity is
          Al finalizar el pedido Más información
          Ahorró ()
           
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          Description
          OverviewExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H2O (Cat. No. 508773).
          Catalogue Number520222
          Brand Family Calbiochem®
          References
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Product Information
          CAS number82188-90-7
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₁H₃₃N₆O₃•2HCl
          Chemical formulaC₂₁H₃₃N₆O₃•2HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationPPACK, Dihydrochloride, CAS 142036-63-3, is a highly potent, selective & irreversible inhibitor of thrombin. Reacts with thrombin in a 1:1 stoichiometry. Can also inhibit tPA, Factors VIIa & XIa.
          Biological Information
          Primary TargetThrombin
          Primary Target IC<sub>50</sub>Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin
          Purity≥80% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          520222-25MG 04055977271294
          520222-5MG 07790788051020

          Documentation

          PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          PPACK, Dihydrochloride - CAS 82188-90-7 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          520222

          Referencias bibliográficas

          Visión general referencias
          Rosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.

          Citas

          Título
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
          		•
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2013 JSW
          DescriptionExtremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 107M-1S-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator. Factor VIIa, and Factor XIa.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number82188-90-7
          Chemical formulaC₂₁H₃₃N₆O₃•2HCl
          Peptide SequenceH-D-Phe-Pro-Arg-chloromethylketone, 2HCl
          Purity≥80% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage Protect from moisture
          Protect from light
          +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.
          Toxicity Standard Handling
          Merck USA index14, 7699
          ReferencesRosado, J. A., et al. 2002. J. Biol. Chem. 277, 42157.
          Odake S., et al. 1995. J. Enzyme Inhib. 9, 17.
          Arni, R.K., et al. 1993. Biochemistry 32, 4727.
          Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
          Schmaier, A.H., et al. 1992. Thromb. Res. 67, 479.
          Collen, D., et al. 1982. J. Lab. Clin. Med. 99, 76.
          Kettner, C., and Shaw, E. 1981. Methods Enzymol. 80, 826.
          Kettner, C., and Shaw, E. 1979. Thromb. Res. 14, 969.
          Citation
        • Mishra, S.K., et al. 2005. Journal of Biological Chemistry 280, 19270.
          		•