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33-054 PIP4-Kinase HTRF Assay

The PIP4 Kinase HTRF Assay kit provides a method for assaying PI(5)P-4 kinases in a homogenous 384 well format. Suitable for screening of potential inhibitors of these enzymes.

PIP4-Kinase HTRF Assay: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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33-054
384 wells  Kit capacity: 384 wells
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      Descripción

      Replacement Information
      Description
      Catalogue Number33-054
      Brand Family Upstate
      Trade Name
      • HTRF
      • Upstate
      DescriptionPIP4-Kinase HTRF Assay
      References
      Product Information
      Components
      • Reaction Buffer (4X)
      • DM A Detection Reagent
      • DM C Detection Reagent
      • DM E Detection Reagent
      • Phosphatidylinositol 5-phosphate (1mM)
      • Phosphatidylserine (1mM)
      • Stop Reagent D
      Detection methodHTRF
      Quality LevelMQ100
      Applications
      ApplicationThe PIP4 Kinase HTRF Assay kit provides a method for assaying PI(5)P-4 kinases in a homogenous 384 well format. Suitable for screening of potential inhibitors of these enzymes.
      Key Applications
      • Kinase Assay
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      Analytes Available
      • PIP4 Kinase
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha
      catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.
      Gene Symbol
      • PIP4K2α
      Target Sub-FamilyPI3K/PI4K
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions12 months at -70°C
      Packaging Information
      Material Size384 wells
      Material PackageKit capacity: 384 wells
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      33-054 04053252374517

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      HTRF™

      Categorías

      Life Science Research > Protein Detection and Quantification > Activity Assays > Kinase Assays
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Enzyme Assay Kits and Reagents