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14-785 PI3 Kinase (p110α/p85α) murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p85α. Coexpressed by baculovirus in Sf21 insect cells. For use in Kinase Assays.

PI3 Kinase (p110α/p85α) murine, 10 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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14-785
10 µg  Also available in 250μg size --call for pricing and availability and reference catalog number 14-785M when ordering the 250μg size.
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-785
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI3 Kinase (p110α/p85α) murine, 10 µg
      OverviewComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110αand untagged, recombinant, full length mouse p85α. Coexpressed by baculovirus in Sf21 insect cells.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationComplex of N-terminal 6His-tagged, recombinant, full-length mouse p110α & untagged, recombinant, full length mouse p85α. Coexpressed by baculovirus in Sf21 insect cells. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceCoexpressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryPhosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
      Gene Symbol
      • PIK3CA
      • PI3K
      • MGC142161
      • p110-alpha
      • MGC142163
      Protein TargetPI3Kα/p85α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
      SIZE: 1068 amino acids; 124284 Da
      SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
      DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
      SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
      Molecular Weightp110α MW = 129kDa, p85α MW = 83.6kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size --call for pricing and availability and reference catalog number 14-785M when ordering the 250μg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-785 04053252274893

      Documentation

      PI3 Kinase (p110α/p85α) murine, 10 µg Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      PI3 Kinase (p110α/p85α) murine, 10 µg Certificados de análisis

      CargoNúmero de lote
      PI 3-Kinase (p110#945;/p85#945;), murine - D8HN028U-C D8HN028U-C
      PI 3-Kinase (p110α/p85α), murine - D8HN028U-D D8HN028U-D

      Licencias necesarias e Información técnica

      Cargo
      Unlocking the Mystery of Cancer: Do the Mutant p110α Subunits of PI3-Kinase Hold the Key?

      Ficha técnica

      Cargo
      PI 3-Kinase HTRF Assay

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      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases