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481412 NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
139141-12-1C₁₅H₁₃FO

Precios y disponibilidad

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481412-10MG
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      Description
      OverviewA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
      Catalogue Number481412
      Brand Family Calbiochem®
      Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
      References
      ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
      Product Information
      CAS number139141-12-1
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₅H₁₃FO
      Chemical formulaC₁₅H₁₃FO
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB Activation
      Primary Target IC<sub>50</sub>150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells.
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      481412-10MG 04055977183726

      Documentation

      NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      481412

      Referencias bibliográficas

      Visión general referencias
      Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2011 RFH
      Synonyms(E)-2-Fluoro-4ʹ-methoxystilbene
      DescriptionA cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM).
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number139141-12-1
      Chemical formulaC₁₅H₁₃FO
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHeynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182.