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481411 NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem

Descripción

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CAS #Empirical Formula
380623-76-7C₁₀H₅ClN₄O₅S

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481411-5MG
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      Description
      OverviewA cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
      Catalogue Number481411
      Brand Family Calbiochem®
      Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
      References
      ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
      Product Information
      CAS number380623-76-7
      ATP CompetitiveN
      FormLight yellow amorphous solid
      Hill FormulaC₁₀H₅ClN₄O₅S
      Chemical formulaC₁₀H₅ClN₄O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetTNF-α-stimulated NF-κB activation and upregulation of MMP-9
      Primary Target IC<sub>50</sub>Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      481411-5MG 04055977183719