Millipore Sigma Vibrant Logo

444283 MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem

The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Pyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)

Primary Target: MMP-13 activity
View Products on Sigmaaldrich.com
444283
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
544678-85-5C₂₂H₂₀F₂N₄O₂

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
444283-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
      Catalogue Number444283
      Brand Family Calbiochem®
      SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
      References
      ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.
      Product Information
      CAS number544678-85-5
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₂₂H₂₀F₂N₄O₂
      Chemical formulaC₂₂H₂₀F₂N₄O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-13 activity
      Primary Target IC<sub>50</sub>8 nM against MMP-13
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      444283-1MG 04055977186000

      Documentation

      MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      444283

      Referencias bibliográficas

      Visión general referencias
      Engel, C.K., et al. 2005. Chem. Biol. 12, 181.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2008 RFH
      SynonymsPyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide)
      DescriptionA potent inhibitor of MMP-13 activity (IC50 = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number544678-85-5
      Chemical formulaC₂₂H₂₀F₂N₄O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute in buffer immediately prior to use.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesEngel, C.K., et al. 2005. Chem. Biol. 12, 181.