Millipore Sigma Vibrant Logo

426100 Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem

Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC₅₀ = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Proteasome Inhibitor VI

Primary Target: 20S proteasome (MCP; multicatalytic proteinase complex)
View Products on Sigmaaldrich.com
426100
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1258004-00-0C₁₅H₂₄N₂O₇S

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
426100-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Frasco de vidrio 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      426100-200UG
      Comprobando disponibilidad...
      —
      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 200 μg
          Recuperando precio...
          No pudo obtenerse el precio
          La cantidad mínima tiene que ser múltiplo de
          Maximum Quantity is
          Al finalizar el pedido Más información
          Ahorró ()
           
          —
          Solicitar precio
          		 —
          426100-400UG
          Comprobando disponibilidad...
          —
          Disponibilidad a confirmar Disponibilidad a confirmar
          Ingrese cantidad 
          Suspendido
          Cantidades limitadas disponibles
          Debe confirmarse disponibilidad
            El resto: se avisará
              El resto: se avisará
              Se avisará
              Póngase en contacto con el Servicio de Atención al Cliente
              Contact Customer Service

              		 Ampolla de plást. 400 μg
              Recuperando precio...
              No pudo obtenerse el precio
              La cantidad mínima tiene que ser múltiplo de
              Maximum Quantity is
              Al finalizar el pedido Más información
              Ahorró ()
               
              —
              Solicitar precio
              		 —
              Description
              OverviewAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM).
              Catalogue Number426100
              Brand Family Calbiochem®
              SynonymsProteasome Inhibitor VI
              References
              ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
              Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
              Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
              Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
              Fenteany, G., et al. 1995. Science 268, 726.
              Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
              Jensen, T.J., et al. 1995. Cell 83, 129.
              Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
              Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
              Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
              Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
              Omura, S., et al. 1991. J. Antibiot. 44, 117.
              Product Information
              CAS number1258004-00-0
              ATP CompetitiveN
              FormWhite solid
              Hill FormulaC₁₅H₂₄N₂O₇S
              Chemical formulaC₁₅H₂₄N₂O₇S
              ReversibleN
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              Biological Information
              Primary Target20S proteasome (MCP; multicatalytic proteinase complex)
              Primary Target IC<sub>50</sub>500 nM against 20S proteasome; 10 µM against NF-κB activation
              Purity≥99% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Número de referencia GTIN
              426100-1MG 04055977187311
              426100-200UG 04055977187328
              426100-400UG 04055977187335

              Documentation

              Licencias necesarias

              Título
              CARTA DE USO GENERAL 2016
              PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

              Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem Ficha datos de seguridad (MSDS)

              Título

              Ficha técnica de seguridad del material (MSDS) 

              Lactacystin, Synthetic - CAS 1258004-00-0 - Calbiochem Certificados de análisis

              CargoNúmero de lote
              426100

              Referencias bibliográficas

              Visión general referencias
              Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
              Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
              Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
              Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
              Fenteany, G., et al. 1995. Science 268, 726.
              Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
              Jensen, T.J., et al. 1995. Cell 83, 129.
              Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
              Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
              Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
              Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
              Omura, S., et al. 1991. J. Antibiot. 44, 117.

              Folleto

              Cargo
              Caspases and other Apoptosis Related Tools Brochure
              Proteasomes Technical Bulletin

              Citas

              Título
            • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
            • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
            • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.
              		•
              Ficha técnica

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision23-October-2012 JSW
              SynonymsProteasome Inhibitor VI
              DescriptionAn irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500 nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells beyond theG1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 µM)
              FormWhite solid
              CAS number1258004-00-0
              Chemical formulaC₁₅H₂₄N₂O₇S
              Structure formulaStructure formula
              Purity≥99% by HPLC
              SolubilityDMSO (50 mg/ml) or H₂O
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C. Unstable in aqueous solutions; reconstitute in H₂O just prior to use.
              Toxicity Standard Handling
              ReferencesKeyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
              Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
              Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
              Oda, K., et al. 1996. Biochem. Biophys. Res. Commun. 219, 800.
              Fenteany, G., et al. 1995. Science 268, 726.
              Imajoh-Ohmi, S., et al. 1995. Biochem. Biophys. Res. Commun. 217, 1070.
              Jensen, T.J., et al. 1995. Cell 83, 129.
              Katagiri, M.M., et al. 1995. J. Antibiot. 48, 344.
              Mori, S., et al. 1995. J. Biol. Chem. 270, 29447.
              Tanaka, H., et al. 1995. Biochem. Biophys. Res. Commun. 216, 291.
              Fenteany, G., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3358.
              Omura, S., et al. 1991. J. Antibiot. 44, 117.
              Citation
            • Keyomarsi, K., et al. 2011. Cell. Biol. Toxicol. 27, 123.
            • Lacher, M.D., et al. 2006. Cancer Research 66, 1648.
            • Wu, C-J., et al. 2005. European Molecular Biology Organization Journal 24, 1886.
              		•