Millipore Sigma Vibrant Logo

658548 InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: Epidermal growth factor receptor kinase
View Products on Sigmaaldrich.com
658548
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
175178-82-2C₁₆H₁₄ClN₃O₂

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
658548-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      Catalogue Number658548
      Brand Family Calbiochem®
      References
      ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
      Product Information
      CAS number175178-82-2
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormClear to faint tan liquid
      FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
      Hill FormulaC₁₆H₁₄ClN₃O₂
      Chemical formulaC₁₆H₁₄ClN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEpidermal growth factor receptor kinase
      Primary Target IC<sub>50</sub>3 nM against of epidermal growth factor receptor kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      658548-1MG 04055977261646

      Documentation

      InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      658548

      Referencias bibliográficas

      Visión general referencias
      Levitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

      Citas

      Título
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
    • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
    • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2008 RFH
      DescriptionHighly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 > 100 µM), the platelet-derived growth factor (PDGF) receptor (IC50 > 100 µM), and p210Bcr-Abl (IC50 >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
      FormClear to faint tan liquid
      FormulationA 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number175178-82-2
      Chemical formulaC₁₆H₁₄ClN₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesLevitski, A., and Gazit, A. 1995. Science 267, 1782.
      Fry, D.W., et al. 1994. Science 265, 1093.
      Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
      Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
      Citation
    • Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.
    • Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.
    • Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.
      		•