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371970 HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties.

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Sinónimos: Fasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII

Primary Target: PKA
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371970
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Descripción

Tabla espec. clave

CAS #Empirical Formula
103745-39-7C₁₄H₁₇N₃O₂S · 2HCl

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371970-1MG
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 36 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
      Catalogue Number371970
      Brand Family Calbiochem®
      SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
      References
      ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
      Swärd, K., et al. 2000. J. Physiol. 522, 33.
      Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
      Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
      Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
      Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
      Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
      Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
      Product Information
      CAS number103745-39-7
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
      Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPKA
      Primary Target IC<sub>50</sub>10.7 µM inhibiting Rho-associated kinase (ROCK)
      Primary Target K<sub>i</sub>.6 µM, 1.6 µM, 36 µM, inhibiting protein kinase A, protein kinase G, myosin light chain kinase, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
      Global Trade Item Number
      Número de referencia GTIN
      371970-1MG 04055977213539