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345733 Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem

Contains mainly N-acetylneuraminic acid.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄

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345733
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₆₄H₁₁₈N₂O₂₁ · NH₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
345733-500UG
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      Description
      OverviewContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
      M.W. 1198.5 (based on stearoyl - 18:0).
      Catalogue Number345733
      Brand Family Calbiochem®
      SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
      References
      ReferencesKatoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase C, EGF-receptor tyrosine kinase
      Primary Target IC<sub>50</sub>100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      345733-500UG 04055977193824

      Documentation

      Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk - Calbiochem Certificados de análisis

      CargoNúmero de lote
      345733

      Referencias bibliográficas

      Visión general referencias
      Katoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

      Folleto

      Cargo
      Gangliosides Technical Bulletin
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2007 RFH
      SynonymsNeu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
      DescriptionContains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC50 = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.
      FormWhite solid
      Chemical formulaC₆₄H₁₁₈N₂O₂₁ · NH₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityChloroform:Methanol (2:1)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesKatoh, N. 1995. Life Sci. 56, 157.
      Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
      Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
      Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.