Millipore Sigma Vibrant Logo

344930 Furin Inhibitor I - Calbiochem

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Furin Inhibitor I - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Decanoyl-RVKR-CMK

Primary Target: viral glycoproteins
View Products on Sigmaaldrich.com
344930
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
344930-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
      Catalogue Number344930
      Brand Family Calbiochem®
      SynonymsDecanoyl-RVKR-CMK
      References
      ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
      Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
      Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
      Garten, W., et al. 1994. Biochimie 76, 217.
      Hallenberger, S., et al. 1992. Nature 360, 358.
      Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
      Product Information
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₄H₆₆ClN₁₁O₅
      Chemical formulaC₃₄H₆₆ClN₁₁O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetviral glycoproteins
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      344930-1MG 04055977194371

      Documentation

      Furin Inhibitor I - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Furin Inhibitor I - Calbiochem Certificados de análisis

      CargoNúmero de lote
      344930

      Referencias bibliográficas

      Visión general referencias
      Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
      Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
      Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
      Garten, W., et al. 1994. Biochimie 76, 217.
      Hallenberger, S., et al. 1992. Nature 360, 358.
      Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 RFH
      SynonymsDecanoyl-RVKR-CMK
      DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
      FormOff-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₃₄H₆₆ClN₁₁O₅
      Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO or Methanol (1 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
      Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
      Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
      Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
      Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
      Garten, W., et al. 1994. Biochimie 76, 217.
      Hallenberger, S., et al. 1992. Nature 360, 358.
      Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.