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14-725 EGFR (T790M) Protein, active, 10 µg

Active, N-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M, for use in Enzyme Assays.

EGFR (T790M) Protein, active, 10 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
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14-725
10 µg  
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-725
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionEGFR (T790M) Protein, active, 10 µg
      OverviewN-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal GST-tagged recombinant human EGF Receptor, amino acids 696end containing the mutation T790M, for use in Enzyme Assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • EGFR
      • ERBB1
      • ERBB
      • mENA
      Protein TargetEGFR
      Purification MethodGlutathione-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.
      SIZE: 1210 amino acids; 134277 Da
      SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.
      PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].
      SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
      MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.
      Molecular Weight86kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDIYFEFMGGKKK)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-725 04053252745010

      Documentation

      EGFR (T790M) Protein, active, 10 µg Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      EGFR (T790M) Protein, active, 10 µg Certificados de análisis

      CargoNúmero de lote
      EGFR (T790M), active (Recombinant enzyme expressed in Sf21 insect cells) - 1654891-D 1654891-D
      EGFR (T790M), active - 042784D 042784D
      EGFR (T790M), active - 042784E 042784E
      EGFR (T790M), active - 0610042784A 0610042784A
      EGFR (T790M), active - 1619357 1619357
      EGFR (T790M), active - 1654891-A 1654891-A

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