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288500 DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: DFMO, Eflornithine, RMI-71782

Primary Target: ODC
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288500
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
96020-91-6C₆H₁₂F₂N₂O₂ · HCl · H₂O

Precios y disponibilidad

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288500-25MG
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      Description
      OverviewA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
      Catalogue Number288500
      Brand Family Calbiochem®
      SynonymsDFMO, Eflornithine, RMI-71782
      References
      ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.
      Product Information
      CAS number96020-91-6
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetODC
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRM2981900
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      288500-25MG 04055977197921

      Documentation

      DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      288500

      Referencias bibliográficas

      Visión general referencias
      Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.

      Folleto

      Cargo
      Pathways and Biomarkers of Oxidative Stress
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2008 JSW
      SynonymsDFMO, Eflornithine, RMI-71782
      DescriptionA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
      FormWhite powder
      CAS number96020-91-6
      RTECSRM2981900
      Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O (1 mg/ml) or Methanol (25 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 3522
      ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.