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AB3252 Anti-c-myc Antibody

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AB3252
100 µg  
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      Descripción

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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WB, ICCChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3252
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-c-myc Antibody
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified chicken IgY. Liquid in PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-c-myc Antibody is a Chicken Polyclonal Antibody for detection of c-myc also known as Proto-oncogene c-Myc & has been tested in IP, WB, ICC.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern blotting (ECL): 1:500

      Immunocytochemistry: 1:250

      Immunoprecipitation: 1:250

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide EQKLISEEDL from human c-myc.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostChicken
      Specificityc-myc
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
      Gene Symbol
      • MYC
      • C-MYC
      • c-Myc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
      SIZE: 439 amino acids; 48804 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Phosphorylated by PRKDC.
      DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots, under sterile conditions, for up to 6 months. Freezing the antibody will result in loss of activity of approximately 50%.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Número de referencia GTIN
      AB3252 04053252406898