Millipore Sigma Vibrant Logo

565781 β-Secretase Substrate VI, Fluorogenic - Calbiochem

A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec⁻¹; Km = 9 µM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: H-K(DABSYL)-SEVNLDAEFRQ(LY)

565781
Ver precios y disponibilidad

Descripción

Replacement Information

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
565781-500UG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 500 μg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL↓DA-). Useful for high throughput screening of β-secretase inhibitors.
      Catalogue Number565781
      Brand Family Calbiochem®
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      References
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Primary Target IC<sub>50</sub>kcat = 0.02 sec⁻¹ and Km = 9 µM at pH ~4.0 as fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      565781-500UG 04055977267297

      Documentation

      β-Secretase Substrate VI, Fluorogenic - Calbiochem Certificados de análisis

      CargoNúmero de lote
      565781

      Referencias bibliográficas

      Visión general referencias
      Grüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      DescriptionA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for b-secretase (BACE) (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL ↓ DA-). Useful for high throughput screening of β-secretase inhibitors. Excitation max.: ~430 nm; emission max.: ~520 nm.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.