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Cell Cycle

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The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist.
The continued turn over of human embryonic stem cells (hESC) while maintaining an undifferentiated state is dependent on the regulation of the cell cycle. Here we asked the question if a single cell cycle gene could regulate the self-renewal or pluripotency properties of hESC. We identified that the protein expression of the p27...
Document Type:

Reference

Product Catalog Number:

AB5922
ES cell cycle progression and differentiation require the action of the histone methyltransferase Dot1L.
Mouse embryonic stem cells (ESCs) proliferate with rapid cell cycle kinetics but without loss of pluripotency. The histone methyltransferase Dot1L is responsible for methylation of histone H3 at lysine 79 (H3K79me). We investigated whether ESCs require Dot1L for proper stem cell behavior. ESCs deficient in Dot1L tolerate a nearl...
Document Type:

Reference

Product Catalog Number:

17-295
Product Catalog Name:

Chromatin Immunoprecipitation (ChIP) Assay Kit
A cell cycle role for the epigenetic factor CTCF-L/BORIS.
CTCF is a ubiquitous epigenetic regulator that has been proposed as a master keeper of chromatin organisation. CTCF-like, or BORIS, is thought to antagonise CTCF and has been found in normal testis, ovary and a large variety of tumour cells. The cellular function of BORIS remains intriguing although it might be involved in devel...
Document Type:

Reference

Product Catalog Number:

07-729
Product Catalog Name:

Anti-CTCF Antibody
Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.
Cyclin D1 and its binding partners CDK4/6 are essential regulators of cell cycle progression and are implicated in cancer progression. Our aim was to investigate a potential regulatory role of these proteins in other essential tumor biological characteristics. Using a panel of breast cancer cell lines and primary human breast ca...
Document Type:

Reference

Product Catalog Number:

MAB8879
Product Catalog Name:

Anti-Cdk4 Antibody, clone DCS-35
Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
The E3 ubiquitin ligase Rad18 mediates tolerance of replication fork-stalling bulky DNA lesions, but whether Rad18 mediates tolerance of bulky DNA lesions acquired outside S-phase is unclear. Using synchronized cultures of primary human cells, we defined cell cycle stage-specific contributions of Rad18 to genome maintenance in r...
Document Type:

Reference

Product Catalog Number:

05-636
Product Catalog Name:

Anti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301
Cell cycle regulation of the murine 8-oxoguanine DNA glycosylase (mOGG1): mOGG1 associates with microtubules during interphase and mitosis.
8-Oxoguanine DNA glycosylase (OGG1) is a major DNA repair enzyme in mammalian cells. OGG1 participates in the repair of 8-oxoG, the most abundant known DNA lesion induced by endogenous reactive oxygen species in aerobic organisms. In this study, antibodies directed against purified recombinant human OGG1 (hOGG1) or murine (mOGG1...
Document Type:

Reference

Product Catalog Number:

MAB1636
Cell cycle regulation of DNA replication initiator factor Dbf4p.
The precise duplication of eukaryotic genetic material takes place once and only once per cell cycle and is dependent on the completion of the previous mitosis. Two evolutionarily conserved kinases, the cyclin B (Clb)/cyclin-dependent kinase (Cdk/Cdc28p) and Cdc7p along with its interacting factor Dbf4p, are required late in G1...
Document Type:

Reference

Product Catalog Number:

AP182F
Cell cycle arrest at the initiation step of human chromosomal DNA replication causes DNA damage.
Cell cycle arrest in response to environmental effects can lead to DNA breaks. We investigated whether inhibition of DNA replication during the initiation step can lead to DNA damage and characterised a cell-cycle-arrest point at the replication initiation step before the establishment of active replication forks. This arrest ca...
Document Type:

Reference

Product Catalog Number:

07-164
Product Catalog Name:

Anti-phospho-H2A.X (Ser139) Antibody
Cell cycle regulated phosphorylation of the telomere-associated protein TIN2.
The protein TIN2 is a member of telomere-binding protein complex that serves to cap and protect mammalian chromosome ends. As a number of proteins in this complex are phosphorylated in a cell cycle-dependent manner, we investigated whether TIN2 is modified by phosphorylation as well. We performed phospho-proteomic analysis of hu...
Document Type:

Reference

Product Catalog Number:

ABE1314
Product Catalog Name:

Anti-phospho TIN2 (Ser295) Antibody
Cell cycle arrest and proapoptotic effects of the anticancer cyclodepsipeptide serratamolide (AT514) are independent of p53 status in breast cancer cells.
In a search for new anticancer agents, we have identified serratamolide (AT514), a cyclodepsipeptide from Serratia marcescens 2170 that induces cell cycle arrest and apoptosis in various cancer cell lines. A cell viability assay showed that the concentrations that cause 50% inhibition (IC50) in human cancer cell lines range from...
Document Type:

Reference

Product Catalog Number:

05-572