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14-326 Src Protein, active, 10 µg

Active, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.

Src Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-326
10 µg  2 vials at 5μg each
Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-326
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSrc Protein, active, 10 µg
      OverviewN-Terminal His6-tagged, recombinant, full-length, human Src.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-Terminal His6-tagged, recombinant, full-length, human Src. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman c-src, expressed in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SRC
      • ASV
      • c-src
      • p60-Src
      • SRC1
      • c-SRC
      • pp60c-src
      Protein TargetSrc
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummarySIZE: 536 amino acids; 59835 Da
      SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
      PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
      SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight61.7kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Src Substrate Peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70°C
      Packaging Information
      Material Size10 µg
      Material Package2 vials at 5μg each
      Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-326M when ordering the 250μg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-326 04053252618802

      Documentation

      Src Protein, active, 10 µg SDS

      Title

      Safety Data Sheet (SDS) 

      Src Protein, active, 10 µg Certificates of Analysis

      TitleLot Number
      Src, active (Recombinant enzyme expressed in Sf21 insect cells) - 2070985-B 2070985-B
      Src, active - 2070985-A 2070985-A
      Src, active - 2070985-C 2070985-C
      Src, active - 2070985-D 2070985-D
      Src, active - 2070985-E 2070985-E
      Src, active - 2070985-F 2070985-F
      Src, active - 2070985-G 2070985-G
      Src, active - D8CN006U-V D8CN006U-V

      References

      Reference overviewPub Med ID
      Protein tyrosine kinases, with emphasis on the Src family.
      Courtneidge, S A
      Semin. Cancer Biol., 5: 239-46 (1994)  1994

      Show Abstract       		7528561 7528561