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551850 Quinacrine, Dihydrochloride - CAS 69-05-6 - Calbiochem

A non-specific phospholipase A2 (PLA2) inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mepacrine

Primary Target: PLA₂
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551850
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
69-05-6C₂₃H₃₀CIN₃O · 2HCl

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551850-100MG
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      Description
      OverviewA non-specific phospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine receptor antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamine oxidase (MAO).
      Catalogue Number551850
      Brand Family Calbiochem®
      SynonymsMepacrine
      References
      ReferencesHolscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161.
      Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33.
      Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 714.
      Product Information
      CAS number69-05-6
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₃H₃₀CIN₃O · 2HCl
      Chemical formulaC₂₃H₃₀CIN₃O · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPLA₂
      Primary Target IC<sub>50</sub>4.4 µM in suppressing glibenclamide-sensitive K+-currents
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAR7875000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsStock solutions are stable for up to 60 h at 20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      551850-100MG 04055977268287

      Documentation

      Quinacrine, Dihydrochloride - CAS 69-05-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Quinacrine, Dihydrochloride - CAS 69-05-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      551850

      References

      Reference overview
      Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161.
      Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33.
      Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 714.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      SynonymsMepacrine
      DescriptionPhospholipase A2 (PLA2) inhibitor. Acts as an acetylcholine antagonist. Suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 µM). Also inhibits monoamide oxidase (MAO).
      FormYellow solid
      CAS number69-05-6
      RTECSAR7875000
      Chemical formulaC₂₃H₃₀CIN₃O · 2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage Protect from light
      +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsStock solutions are stable for up to 60 h at 20°C.
      Toxicity Harmful
      Merck USA index14, 8044
      ReferencesHolscher, C. 1995. Neurobiol. Learn. Mem. 63, 206.
      Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117.
      Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161.
      Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33.
      Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 714.