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851009 PyBOP

Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
8510090025
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      Plastic bottle 25 g
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      8510090100
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          Plastic bottle 100 g
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          8510090500
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              Plastic bottle 500 g
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              8510091000
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                  Plastic bottle 1 kg
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                  8510095000
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                      Plastic bottle 5 kg
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                      8510099025
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                          Fibre carton 25 kg
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                          Description
                          Catalogue Number851009
                          Replaces01-62-0016
                          Brand Family Novabiochem®
                          Alternate Names
                          • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
                          Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

                          The product number for this product was previously 01-62-0016.

                          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
                          References
                          Product Information
                          CAS number128625-52-5
                          Hill FormulaC₁₈H₂₈N₆OP * F₆P
                          Molar Mass520.39 g/mol
                          HS Code2933 99 80
                          Structure formula ImageStructure formula Image
                          Quality LevelMQ400
                          Applications
                          ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
                          Biological Information
                          Physicochemical Information
                          Density1.438 g/cm3 (20 °C)
                          Melting Point140 - 155 °C
                          Vapor pressure<1 hPa (25 °C)
                          Dimensions
                          Materials Information
                          Toxicological Information
                          Safety Information according to GHS
                          Hazard Pictogram(s) Hazard Pictogram(s)
                          Hazard Pictogram(s)
                          Hazard Statement(s)H302: Harmful if swallowed.
                          H317: May cause an allergic skin reaction.
                          H410: Very toxic to aquatic life with long lasting effects.
                          Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
                          P264: Wash skin thoroughly after handling.
                          P273: Avoid release to the environment.
                          P280: Wear protective gloves.
                          P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
                          P302 + P352: IF ON SKIN: Wash with plenty of water.
                          Signal WordWarning
                          Storage class10 - 13 Other liquids and solids
                          WGKWGK 3 highly hazardous to water
                          Safety Information
                          Categories of dangerirritant
                          Product Usage Statements
                          Storage and Shipping Information
                          StorageStore at +2°C to +8°C.
                          Packaging Information
                          Transport Information
                          Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
                          Declaration (transport by air) IATA-DGRUN 3077 , 9, III
                          Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
                          Supplemental Information
                          Specifications
                          Color (visual)white to slight yellow to beige
                          Appearance of substance (visual)powder
                          Identity (IR)passes test
                          Assay (HPLC, area%)≥ 99.0 % (a/a)
                          Solubility (1 mmole in 2 ml DMF)clearly soluble
                          Global Trade Item Number
                          Catalogue Number GTIN
                          8510090025 04027269081089
                          8510090100 04027269081096
                          8510090500 04027269178611
                          8510091000 04027269131296
                          8510095000 04027269137878
                          8510099025 04027269176198

                          Documentation

                          PyBOP SDS

                          Title

                          Safety Data Sheet (SDS) 

                          PyBOP Certificates of Analysis

                          Product Number PackagingSpecificationLot Number
                          8510090025 Plastic bottlePDF Specification Document
                          8510090100 Plastic bottlePDF Specification Document
                          8510090500 Plastic bottlePDF Specification Document
                          8510091000 Plastic bottlePDF Specification Document
                          8510095000 Plastic bottlePDF Specification Document
                          8510099025 Fibre cartonPDF Specification Document

                          Brochure

                          Title
                          Novabiochem Coupling Reagent Flyer 2010
                          Novabiochem Innovations 02/06
                          Novabiochem Innovations 03/10
                          Novabiochem Letters 01/14

                          Citations

                          Title
                          • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
                          • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
                          • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
                          • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
                          • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.