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480010 NDSB-256 - CAS 81239-45-4 - Calbiochem

A non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.

NDSB-256 - CAS 81239-45-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dimethylbenzylammonium Propane Sulfonate

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
81239-45-4C₁₂H₁₉NO₃S

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      480010-5GM
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          Description
          OverviewA non-detergent sulfobetaine. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. Zwitterionic over a wide pH range. Easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
          Catalogue Number480010
          Brand Family Calbiochem®
          SynonymsDimethylbenzylammonium Propane Sulfonate
          References
          ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.
          Product Information
          CAS number81239-45-4
          FormWhite solid
          Hill FormulaC₁₂H₁₉NO₃S
          Chemical formulaC₁₂H₁₉NO₃S
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥99% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +15°C to +30°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          480010-25GM 07790788050610
          480010-5GM 04055977201802

          Documentation

          NDSB-256 - CAS 81239-45-4 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          NDSB-256 - CAS 81239-45-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          480010

          References

          Reference overview
          Goldberg, M.E., et al. 1996. Folding & Design 1, 21.

          Brochure

          Title
          Biological Detergents Brochure
          Bulk Product Guide
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision02-April-2012 JSW
          SynonymsDimethylbenzylammonium Propane Sulfonate
          DescriptionA member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations. NDSBs have been used to improve the efficiency of solubilization of membrane proteins, to isolate nuclear proteins, to chromatographically purify halophilic proteins in low ionic strength buffers, and to crystallize proteins. They are zwitterionic over a wide pH range and do not absorb significantly in the near UV range. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins. NDSBs can be easily removed by dialysis. At 1 M, NDSB-256 will restore 30% of the enzymatic activity of denatured egg white lysozyme; at 800 mM it will restore 16% of the enzymatic activity of denatured β-galactosidase.
          FormWhite solid
          CAS number81239-45-4
          Chemical formulaC₁₂H₁₉NO₃S
          Structure formulaStructure formula
          Purity≥99% by TLC
          SolubilityH₂O (200 mg/ml)
          Storage +15°C to +30°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store at room temperature (15-30°C). Stock solutions are stable for up to 3 months at room temperature.
          Toxicity Irritant
          ReferencesGoldberg, M.E., et al. 1996. Folding & Design 1, 21.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Biochemicals > Detergents > Non-Detergent Sulfobetaines