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616382 Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem

Inhibits trypsin-like serine proteinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TLCK

Primary Target: trypsin like proteases
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616382
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Overview

Key Spec Table

CAS #Empirical Formula
4238-41-9C₁₄H₂₁ClN₂O₃S . HCl

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616382-250MG
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      616382-50MG
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      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
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          Description
          OverviewInhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80 µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
          Catalogue Number616382
          Brand Family Calbiochem®
          SynonymsTLCK
          References
          ReferencesGriscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Kim, H., et al. 1995. J. Immunol. 154, 4741.
          Bourinbaiar, A.S. and Nagorny, R. 1994. Cell Immunol. 155, 230.
          Biro, A., et al. 1992. Eur. J. Immunol. 22, 2547.
          Bruno, S., et al. 1992. Leukemia 6, 1113.
          Lee, S.F. 1992. Infect. Immun. 60, 4032.
          Schmidt, H.H., et al. 1992. Mol. Pharmacol. 41, 615.
          Product Information
          CAS number4238-41-9
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₄H₂₁ClN₂O₃S . HCl
          Chemical formulaC₁₄H₂₁ClN₂O₃S . HCl
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary Targettrypsin like proteases
          Primary Target IC<sub>50</sub>EC50 = 80 µM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages
          Purity≥95% by elemental analysis
          Physicochemical Information
          Cell permeableN
          Safety Information according to GHS
          RTECSXT5160000
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsUnstable in solution; reconstitute just prior to use.
          Global Trade Item Number
          Catalogue Number GTIN
          616382-250MG 04055977186284
          616382-50MG 04055977186291