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475856 Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem

The Mitochondrial Division Inhibitor, mdivi-1, also referenced under CAS 338967-87-6, controls the biological activity of yeast Dnm1 and mammalian Drp1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor

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475856
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Overview

Key Spec Table

CAS #Empirical Formula
338967-87-6C₁₅H₁₀Cl₂N₂O₂S

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475856-10MG
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      Description
      OverviewA cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.
      Catalogue Number475856
      Brand Family Calbiochem®
      Synonyms3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor
      References
      ReferencesCassidy-Stone A., et al. 2008. Dev. Cell 14, 193.
      Product Information
      CAS number338967-87-6
      FormWhite solid
      Hill FormulaC₁₅H₁₀Cl₂N₂O₂S
      Chemical formulaC₁₅H₁₀Cl₂N₂O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      475856-10MG 07790788056377