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FCMAB135F Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10

Detect BMP-7 using this Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Mesenchymal Stem Cells Gene Symbol: BMP7, OP1 UniProt Number: P18075
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FCMAB135F
100 tests  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB135F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark Anti-BMP-7-FITC Antibody, clone 2A10
      Alternate Names
      • Bone morphogenetic protein-7
      • osteogenic protein-1
      Background InformationBone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.
      References
      Product Information
      FormatFITC
      Control
      • HeLa cells.
      PresentationPurified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationDetect BMP-7 using this Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 validated for use in FC.
      Key Applications
      • Flow Cytometry
      Working Solution Cells / test Total Reaction Volume
      5 μl 5 x 105 Cells / 95 μl PBS 100 μl
      10 μl 1 x 106 Cells / 90 μl PBS 100 μl
      Biological Information
      Immunogen Recombinant full-length BMP-7 protein.
      EpitopeUnknown
      Clone2A10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis monoclonal antibody recognizes BMP-7.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteTested and passed on Human. Unconjugated antibody (MAB4350) also reacts against Mouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BMP7
      • OP1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFunction Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

      Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.

      Subcellular location Secreted.

      Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.

      Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

      Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

      Sequence similarities Belongs to the TGF-beta family.
      Molecular Weight 46kDa Observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using HeLa cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB135F 04053252699931

      Documentation

      Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-BMP-7-FITC, clone 2A10 - 2067779 2067779
      Milli-Mark Anti-BMP-7-FITC, clone 2A10 - 1959240 1959240
      Milli-Mark Anti-BMP-7-FITC, clone 2A10 - 2207208 2207208
      Milli-Mark Anti-BMP-7-FITC, clone 2A10 - NG1875695 NG1875695
      Milli-Mark Anti-BMP-7-FITC, clone 2A10 - NRG1724874 NRG1724874
      Milli-Mark™ Anti-BMP-7-FITC, -2776279 2776279
      Milli-Mark™ Anti-BMP-7-FITC, -2782656 2782656
      Milli-Mark™ Anti-BMP-7-FITC, -2801954 2801954
      Milli-Mark™ Anti-BMP-7-FITC, -2804293 2804293
      Milli-Mark™ Anti-BMP-7-FITC, clone 2A10 3103993
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