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440025 Luteolin - CAS 491-70-3 - Calbiochem

An antioxidant flavonoid and a free radical scavenger.

Luteolin - CAS 491-70-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3ʹ,4ʹ,5,7-Tetrahydroxyflavone

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440025
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
491-70-3C₁₅H₁₀O₆

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440025-5MG
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      		 Glass bottle 5 mg
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      Description
      OverviewAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
      Catalogue Number440025
      Brand Family Calbiochem®
      Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
      References
      ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
      Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
      Plaumann, B., et al. 1996. Oncogene 13, 1605.
      Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
      Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.
      Product Information
      CAS number491-70-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₅H₁₀O₆
      Chemical formulaC₁₅H₁₀O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetrat liver cytosolic glutathione S-transferase activity
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLK9275210
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440025-5MG 04055977187090

      Documentation

      Luteolin - CAS 491-70-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Luteolin - CAS 491-70-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      440025

      References

      Reference overview
      Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
      Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
      Plaumann, B., et al. 1996. Oncogene 13, 1605.
      Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
      Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-July-2011 JSW
      Synonyms3ʹ,4ʹ,5,7-Tetrahydroxyflavone
      DescriptionAn antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T1/2CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number491-70-3
      RTECSLK9275210
      Chemical formulaC₁₅H₁₀O₆
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityAqueous alkaline solutions (1.4 mg/ml), DMSO (7 mg/ml), or Ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 5614
      ReferencesKim, J.E., et al. 2011. J. Pharmacol. Exp. Ther. in press.
      Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol. 38, 151.
      Plaumann, B., et al. 1996. Oncogene 13, 1605.
      Ramanathan, R., et al. 1994. Free Radic. Biol. Med. 16, 43.
      Shimoi, L., et al. 1994. Carcinogenesis 15, 2669.