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524644 L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

A component of membrane-bound receptors in association with phospholipase C (PLC).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PIP₂

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524644
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Overview

Key Spec Table

CAS #Empirical Formula
383907-42-4C₄₇H₈₂O₁₉P₃ · 3NH₄

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524644-100UG
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      524644-1MG
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          Description
          OverviewA component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
          Catalogue Number524644
          Brand Family Calbiochem®
          SynonymsPIP₂
          References
          ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
          Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
          Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
          Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
          Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
          Williamson, J.R. 1986. Hypertension 8, 140.
          Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
          Product Information
          CAS number383907-42-4
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₄₇H₈₂O₁₉P₃ · 3NH₄
          Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary TargetBrain phospholipase D (PLD)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableN
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Irritant
          Storage ≤ -70°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          524644-100UG 04055977197624
          524644-1MG 04055977197617