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553211 InSolution™ Rapamycin - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 553211) on sigmaaldrich.com.

InSolution™ Rapamycin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: mTOR Inhibitor I

Primary Target: Mammalian target of rapamycin (mTOR)
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553211
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₁H₇₉NO₁₃

Pricing & Availability

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553211-500UG
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      Description
      Catalogue Number553211
      Brand Family Calbiochem®
      SynonymsmTOR Inhibitor I
      References
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
      Hill FormulaC₅₁H₇₉NO₁₃
      Chemical formulaC₅₁H₇₉NO₁₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMammalian target of rapamycin (mTOR)
      Primary Target IC<sub>50</sub>50 pM inhibiting the mammalian target of rapamycin (mTOR) and blocking the subsequent activation of p70 S6 kinase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      553211-500UG 04055977193558

      Documentation

      Required Licenses

      Title
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SAGARPA
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Rapamycin - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Rapamycin - Calbiochem Certificates of Analysis

      TitleLot Number
      553211

      Citations

      Title
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      SynonymsmTOR Inhibitor I
      DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
      FormLiquid
      FormulationA 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅₁H₇₉NO₁₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
      Toxicity Irritant
      Citation
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
    • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
      		•