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440204 InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem

InSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

Primary Target: phosphatidylinositol 3-kinase
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440204
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154447-36-6C₁₉H₁₇NO₃

Pricing & Availability

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440204-1MG
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      		 Plastic ampoule 1 mg
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      Description
      Catalogue Number440204
      Brand Family Calbiochem®
      Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
      References
      ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
      Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
      Cardone, M.H., et al. 1998. Science 282, 1318.
      Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
      Yano, H., et al. 1995. Biochem. J. 312, 145.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Product Information
      CAS number154447-36-6
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
      Hill FormulaC₁₉H₁₇NO₃
      Chemical formulaC₁₉H₁₇NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).
      Biological Information
      Primary Targetphosphatidylinositol 3-kinase
      Primary Target IC<sub>50</sub>1.4 µM against phosphatidylinositol 3-kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      440204-1MG 04055977186710

      Documentation

      Required Licenses

      Title
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SAGARPA
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      440204

      References

      Reference overview
      Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
      Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
      Cardone, M.H., et al. 1998. Science 282, 1318.
      Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
      Yano, H., et al. 1995. Biochem. J. 312, 145.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.

      Citations

      Title
    • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
    • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
    • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
    • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2008 RFH
      Synonyms2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
      FormLiquid
      FormulationA 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number154447-36-6
      Chemical formulaC₁₉H₁₇NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesDittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
      Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
      Cardone, M.H., et al. 1998. Science 282, 1318.
      Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
      Yano, H., et al. 1995. Biochem. J. 312, 145.
      Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.



      Selected Citations
      Lee, J., et al. 2009. Cell Stem Cell 5, 76.
      Citation
    • Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.
    • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
    • Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
    • Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.
    • Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.
      		•