Millipore Sigma Vibrant Logo

218708 InSolution™ Casein Kinase II Inhibitor I - Calbiochem

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆HBr₄N₃

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
218708-5MG
Retrieving availability...
Limited Availability
Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      Catalogue Number218708
      Brand Family Calbiochem®
      References
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
      Product Information
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Hill FormulaC₆HBr₄N₃
      Chemical formulaC₆HBr₄N₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCK2 rat liver, human recombinant
      Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively
      PuritySingle spot by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218708-5MG 07790788048587

      Documentation

      Required Licenses

      Title
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SAGARPA
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Casein Kinase II Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      218708

      References

      Reference overview
      Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418."
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      DescriptionA cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
      FormLiquid
      FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆HBr₄N₃
      Structure formulaStructure formula
      PuritySingle spot by TLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Carcinogenic / Teratogenic
      ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
      Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
      Sarno, S., et al. 2003. Biochem. J. 374, 639.
      Sarno, S., et al. 2001. FEBS Lett. 496, 44.
      Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.