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407616 IL-1R Antagonist - CAS 566914-00-9 - Calbiochem

IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic

Primary Target: TIR domain-mediated MyD88/IL1-RI interaction
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407616
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
566914-00-9C₁₈H₂₆N₂O₂

Pricing & Availability

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407616-25MG
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      Description
      OverviewA cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
      Catalogue Number407616
      Brand Family Calbiochem®
      SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
      References
      ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
      Product Information
      CAS number566914-00-9
      ATP CompetitiveN
      FormColorless oil
      Hill FormulaC₁₈H₂₆N₂O₂
      Chemical formulaC₁₈H₂₆N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationIL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
      Biological Information
      Primary TargetTIR domain-mediated MyD88/IL1-RI interaction
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407616-25MG 04055977211344

      Documentation

      IL-1R Antagonist - CAS 566914-00-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      IL-1R Antagonist - CAS 566914-00-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      407616

      References

      Reference overview
      Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsBB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
      DescriptionA cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
      FormColorless oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number566914-00-9
      Chemical formulaC₁₈H₂₆N₂O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7971.