361550 Sigma-AldrichGSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem
BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells.
More>> BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Maintains self-renewal in human & mouse embryonic stem cells. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 667463-62-9 | C₁₆H₁₀BrN₃O₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 361550-1MG |
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Plastic ampoule | 1 mg |
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| Description | |
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| Overview | A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available. |
| Catalogue Number | 361550 |
| Brand Family | Calbiochem® |
| Synonyms | BIO, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-oxime |
| Product Information | |
|---|---|
| CAS number | 667463-62-9 |
| ATP Competitive | Y |
| Form | Purple solid |
| Hill Formula | C₁₆H₁₀BrN₃O₂ |
| Chemical formula | C₁₆H₁₀BrN₃O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | GSK-3α/β |
| Primary Target IC<sub>50</sub> | 5 nM against GSK-3α/β |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
| S Phrase | S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 361550-1MG | 04055977214062 |
Documentation
GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem SDS
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GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 361550 |
References
| Reference overview |
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| Tseng, A-S., et al. 2006. Chem. Biol. 13, 957. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Sato, N., et al. 2004. Nat. Med. 10, 55. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |
Citations
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