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324688 Ellipticine - CAS 519-23-3 - Calbiochem

A cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage.

Ellipticine - CAS 519-23-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole

Primary Target: topoisomerase 2
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324688
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
519-23-3C₁₇H₁₄N₂

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324688-10MG
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      Description
      OverviewA cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
      Catalogue Number324688
      Brand Family Calbiochem®
      Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
      References
      ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
      Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
      Pommier, Y., et al. 1985. Biochemistry 24, 6406.
      Product Information
      CAS number519-23-3
      ATP CompetitiveN
      FormBright yellow solid
      Hill FormulaC₁₇H₁₄N₂
      Chemical formulaC₁₇H₁₄N₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targettopoisomerase 2
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUU8825000
      Safety Information
      R PhraseR: 23/24/25-40

      Toxic by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324688-10MG 04055977196863

      Documentation

      Required Licenses

      Title
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Ellipticine - CAS 519-23-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ellipticine - CAS 519-23-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      324688

      References

      Reference overview
      Froelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
      Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
      Pommier, Y., et al. 1985. Biochemistry 24, 6406.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-January-2013 JSW
      Synonyms5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
      DescriptionA topoisomerase II inhibitor. Acts as an intercalative alkaloid that stimulates topoisomerase II-mediated DNA breakage. Is also capable of uncoupling mitochondrial oxidative phosphorylation.
      FormBright yellow solid
      CAS number519-23-3
      RTECSUU8825000
      Chemical formulaC₁₇H₁₄N₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 3548
      ReferencesFroelich-Ammon, S.J., et al. 1995. J. Biol. Chem. 270, 14998.
      Schwaller, M.A., et al. 1995. J. Biol. Chem. 270, 22709.
      Pommier, Y., et al. 1985. Biochemistry 24, 6406.