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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66701-25-5C₁₅H₂₇N₅O₅

Pricing & Availability

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324890-1MG
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      324890-5MG
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          Description
          OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
          Catalogue Number324890
          Brand Family Calbiochem®
          Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
          References
          ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Barrett, A.J. 1982. Biochem. J. 201, 189.
          Product Information
          CAS number66701-25-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₅H₂₇N₅O₅
          Chemical formulaC₁₅H₂₇N₅O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
          Biological Information
          Primary Targetcysteine proteases
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRR0390000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          324890-1MG 04055977196146
          324890-5MG 04055977196177

          Documentation

          E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          324890

          References

          Reference overview
          Matsumoto, K., et al. 1999. Biopolymers 51, 99.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Barrett, A.J. 1982. Biochem. J. 201, 189.

          Citations

          Title
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2013 JSW
          Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
          DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
          FormWhite solid
          CAS number66701-25-5
          RTECSRR0390000
          Chemical formulaC₁₅H₂₇N₅O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Barrett, A.J. 1982. Biochem. J. 201, 189.
          Citation
        • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
          		•