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317640 Dipeptidyl Peptidase IV (CD26), Porcine Kidney

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317640
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317640-250MIU
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      Description
      OverviewNative, DPP IV purified from porcine kidney (renal brush border of the proximal tubule). A serine exopeptidase dimer composed of two identical subunits of 110-130 kDa. Cleaves Xaa-Pro dipeptides from the N-terminus of oligo and polypeptides. DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, T cell activation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes. MW: ~210000-260000 (unreduced).
      Catalogue Number317640
      Brand Family Calbiochem®
      SynonymsCD26, DPPIV
      References
      ReferencesBar, J., et al. 2003. Biol. Chem. 384, 1553.
      Engel, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 5063.
      Ikehara, Y., et al. 1994. Methods. Enzymol. 244, 215.
      David, F., et al. 1993. J. Biol. Chem. 268, 17247.
      Thomsen, P.D., et al. 1993. Mamm. Genome 4, 604.
      Misumi, Y., et al. 1992. Biochim. Biophys. Acta. 1131, 333.
      Seidl, R., et al. 1991. Biol. Chem. Hoppe Seyler 372, 213.
      Checler, F., et al. 1985. J. Neurochem. 45, 1509.
      Imai, K., et al. 1983. J. Biochem. 93, 431.
      Kato, T., et al. 1979. Experientia. 35, 409.
      Kojima, K., et al. 1979. Anal. Biochem. 100, 43.
      Kato, T., et al. 1978. Biochem. Med. 19, 351.
      Kenny, A.J., et al. 1976. Biochem. J. 157, 169.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmole 7-(Gly-Pro)-amino-4-methylcoumarinamide per min at 37°C, pH 8.5.
      EC number3.4.14.5
      FormLiquid
      FormulationIn 20 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% NaN₃, pH 8.0.
      Quality LevelMQ100
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥35 units/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsDilute only the amount of enzyme needed for each assay. Upon thawing, do not re-freeze, store in the refrigerator (4°C).
      Global Trade Item Number
      Catalogue Number GTIN
      317640-250MIU 04055977216257