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217708 Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
71203-35-5C₂₂H₂₁N₃O₃S

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217708-25MG
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      Description
      OverviewA cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM.
      Catalogue Number217708
      Brand Family Calbiochem®
      SynonymsCID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
      References
      ReferencesHong, L., et al. 2012. J. Biol. Chem. in press.
      Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2010 Feb 27. (http://www.ncbi.nlm.nih.gov/books/NBK51965/)
      Product Information
      CAS number71203-35-5
      FormYellow-white solid
      Hill FormulaC₂₂H₂₁N₃O₃S
      Chemical formulaC₂₂H₂₁N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      217708-25MG 04055977202366