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220201 CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem

CAS 75621-03-3 is a zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate

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220201
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75621-03-3C₃₂H₅₈N₂O₇S

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                  220201-5GM
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                      Description
                      OverviewZwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than structurally-related carboxylic acid anions and is much more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100 Detergent. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding of opiates. Also, capable of disaggregating cytochrome P450 to its monomeric form without denaturation. Has a small micellar molecular weight and a high critical micellar concentration and can be removed from either gels or protein solutions by dialysis across a membrane. Aggregation number: 4-14.
                      Conductivity (1.0 M, 24°C): <100 µmhos.
                      Catalogue Number220201
                      Brand Family Calbiochem®
                      Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                      References
                      ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.
                      Product Information
                      CAS number75621-03-3
                      Aggregation Number4 - 14
                      CMC6 - 10 mM
                      FormWhite crystalline powder
                      Hill FormulaC₃₂H₅₈N₂O₇S
                      Chemical formulaC₃₂H₅₈N₂O₇S
                      Hygroscopic Hygroscopic
                      Micellar weight6150
                      Quality LevelMQ300
                      Applications
                      Biological Information
                      Purity≥98% by NMR
                      Physicochemical Information
                      ContaminantsDNase, RNase, and Protease: none detected
                      Dimensions
                      Materials Information
                      Toxicological Information
                      Safety Information according to GHS
                      Safety Information
                      R PhraseR: 22-36/38

                      Harmful if swallowed.
                      Irritating to eyes and skin.
                      S PhraseS: 26-36

                      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                      Wear suitable protective clothing.
                      Product Usage Statements
                      Storage and Shipping Information
                      Ship Code Ambient Temperature Only
                      Toxicity Harmful
                      Storage +15°C to +30°C
                      Hygroscopic Hygroscopic
                      Do not freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                      Packaging Information
                      Transport Information
                      Supplemental Information
                      Specifications
                      Global Trade Item Number
                      Catalogue Number GTIN
                      220201-10GM 07790788048754
                      220201-1GM 04055977200973
                      220201-1KG 04055977200980
                      220201-25GM 04055977201000
                      220201-5GM 04055977201024

                      Documentation

                      CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem SDS

                      Title

                      Safety Data Sheet (SDS) 

                      CHAPS, Molecular Biology Grade - CAS 75621-03-3 - Calbiochem Certificates of Analysis

                      TitleLot Number
                      220201

                      References

                      Reference overview
                      Chen, Y., et al. 1992. Biochemistry 31, 2415.
                      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.

                      Brochure

                      Title
                      Biological Detergents Brochure
                      Bulk Product Guide
                      CALBIOSORBﾙ Technical Bulletin
                      Data Sheet

                      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

                      Revision12-November-2010 RFH
                      Synonyms3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
                      DescriptionNon-denaturing zwitterionic detergent that combines features of bile salts and N-alkyl sulfobetaines. Better at solubilizing proteins than the structurally related carboxylic acid anions, and is more effective at breaking protein-protein interactions than either sodium cholate or TRITON® X-100. Capable of solubilizing the opiate receptor to a state exhibiting reversible binding to opiates. Also capable of disaggregating P 450 to its monomeric form without denaturation. Has a small micellar molecular weight (6150 Daltons) and a high critical micellar concentration (6-10 mM). Can be removed from either gels or protein solutions by dialysis. Aggregation number: 4-14.
                      FormWhite crystalline powder
                      CAS number75621-03-3
                      Chemical formulaC₃₂H₅₈N₂O₇S
                      Purity≥98% by NMR
                      ContaminantsDNase, RNase, and Protease: none detected
                      SolubilityH₂O (1.0 M)
                      Storage +15°C to +30°C
                      Hygroscopic
                      Do Not Freeze Ok to freeze
                      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
                      Toxicity Harmful
                      Merck USA index14, 2044
                      ReferencesChen, Y., et al. 1992. Biochemistry 31, 2415.
                      Ofri, D., et al. 1992. J. Neurochem. 58, 628.
                      Ransom, R.W., et al. 1992. Biochem. Pharmacol. 43, 1823.
                      Simonds, W.F., et al. 1992. Proc. Natl. Acad. Sci. USA 77, 4623.
                      Yannariello-Brown, J., and Weigel, P.H. 1992. Biochemistry 31, 576.
                      Hjelmeland, L.M. 1980. Proc. Natl. Acad. Sci. USA 77, 6368.
                      Simonds, W.F., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 4623.