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MAB1962Z Anti-Integrin β2 Antibody, clone P4H9, azide free

Anti-Integrin β2 Antibody, clone P4H9, azide free detects level of Integrin β2 & has been published & validated for use in IH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB2, LFA-1, MAC-1, MF17, LCAMB, MFI7, LAD, CD18 UniProt Number: P05107
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MAB1962Z
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1962Z
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin β2 Antibody, clone P4H9, azide free
      Alternate Names
      • CD18
      • MAB1962
      References
      Product Information
      FormatPurified
      PresentationSterile-filtered liquid containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Integrin β2 Antibody, clone P4H9, azide free detects level of Integrin β2 & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      • Affects Function
      Application NotesSuitable for use in immunofluorescence.

      Also suitable for aggregation inhibition assays using hematopoeitic cells or EBV-transformed B lymphocytes.

      For extensive dilution, protein-containing or other stabilizing medium should be used. Final working dilutions must be determined by end user.
      Biological Information
      CloneP4H9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      Specificitybeta2 integrin on hematopoeitic cells. Not present on platelets, endothelial cells, epithelial cells or fibroblasts.
      IsotypeIgG3
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe ITGB2 protein product is the integrin beta chain beta 2. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
      Gene Symbol
      • ITGB2
      • LFA-1
      • MAC-1
      • MF17
      • LCAMB
      • MFI7
      • LAD
      • CD18
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05107 # Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1.
      SIZE: 769 amino acids; 84782 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.DISEASE:SwissProt: P05107 # Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
      SIMILARITY: SwissProt: P05107 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB1962Z 04053252610967