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124020 Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-DEBC HC, 10-NCP

Primary Target: Akt
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124020
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Overview

Key Spec Table

CAS #Empirical Formula
925681-41-0C₂₀H₂₅ClN₂O • HCl

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124020-5MG
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      Description
      OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
      Catalogue Number124020
      Brand Family Calbiochem®
      Synonyms10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-DEBC HC, 10-NCP
      References
      ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
      Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
      Product Information
      CAS number925681-41-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₂₅ClN₂O • HCl
      Chemical formulaC₂₀H₂₅ClN₂O • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAkt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.
      Biological Information
      Primary TargetAkt
      Primary Target IC<sub>50</sub><5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
      Secondary targetRn cell lines (IC₅₀ = 2-5 µM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      124020-5MG 04055977205749