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116812 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt - CAS 93882-12-3 - Calbiochem

Cell-permeable cAMP analog that activates both protein kinase A and protein kinase G.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt

Primary Target: Protein kinase A and protein kinase G
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116812
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Overview

Key Spec Table

CAS #Empirical Formula
93882-12-3C₁₆H₁₄ClN₅O₆PS · Na

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116812-10MG
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      Description
      OverviewCell-permeable cAMP analog that activates both protein kinase A and protein kinase G. Directly activates Epac, a Rap1 guanine-nucleotide exchange factor. Also acts as a potent inhibitor of cGMP-specific phosphodiesterase (IC50 = 900 nM). Inhibits cAMP-specific phosphodiesterase at much higher concentrations (IC50 = 25 µM).
      Catalogue Number116812
      Brand Family Calbiochem®
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-(4-Chlorophenylthio)-, Sodium Salt
      References
      Referencesde Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Moed, P.J., et al. 1993. Comp. Biochem. Physiol. 105A, 711.
      Connolly, B.J., et al. 1992. Biochem. Pharmacol. 44, 2303.
      Phillips, M.E., and Taylor, A. 1992. J. Physiol. 456, 591.
      Shipston, M.J., and Antoni, F.A. 1992. Endocrinology 130, 2213.
      Datta, R., et al. 1991. Blood 78, 83.
      Peters, D.J.M., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 9219.
      Sandberg, M., et al. 1991. Biochem. J. 279, 521.
      Unterman, T.G., et al. 1991. Endocrinology 128, 2693.
      Xu, H., et al. 1989. Brain Res. 504, 36.
      Product Information
      CAS number93882-12-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₁₄ClN₅O₆PS · Na
      Chemical formulaC₁₆H₁₄ClN₅O₆PS · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetProtein kinase A and protein kinase G
      Primary Target IC<sub>50</sub>900 nM against cGMP-specific phosphodiesterase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C
      Global Trade Item Number
      Catalogue Number GTIN
      116812-10MG 04055977208238