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393204 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HNE, 4-Hydroxy-2-nonenal

Primary Target: Na+, K+-ATPase activity
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393204
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
75899-68-2C₉H₁₆O₂

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393204-1MG
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      Description
      OverviewA major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
      Catalogue Number393204
      Brand Family Calbiochem®
      SynonymsHNE, 4-Hydroxy-2-nonenal
      References
      ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
      Product Information
      CAS number75899-68-2
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied at 10 mg/ml in ethanol
      Hill FormulaC₉H₁₆O₂
      Chemical formulaC₉H₁₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+, K+-ATPase activity
      Primary Target IC<sub>50</sub>120 µM against Na+, K+-ATPase activity
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRA8510000
      Safety Information
      R PhraseR: 11

      Highly flammable.
      S PhraseS: 7-16

      Keep container tightly closed.
      Keep away from sources of ignition - No Smoking.
      Product Usage Statements
      Storage and Shipping Information
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      393204-1MG 04055977212471

      Documentation

      Required Licenses

      Title
      CARTA DE USO GENERAL 2016
      PRODUCTO REGULADO POR LA SAGARPA
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      393204

      References

      Reference overview
      Soh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsHNE, 4-Hydroxy-2-nonenal
      DescriptionA major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca2+. Irreversibly inhibits Na+-K+-ATPase activity (IC50 = 120 µM).
      FormLiquid
      FormulationSupplied at 10 mg/ml in ethanol
      CAS number75899-68-2
      RTECSRA8510000
      Chemical formulaC₉H₁₆O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (10 mg/ml)
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.