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516705 o-Phenanthroline - CAS 5144-89-8 - Calbiochem

A metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1,10-Phenanthroline Monohydrate

Primary Target: Metalloprotease inhibitor
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516705
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Tableau de caractéristiques principal

CAS #Empirical Formula
5144-89-8C₁₂H₈N₂ · H₂O

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516705-500MG
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      Description
      OverviewA metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a metalloprotease inhibitor. Inhibits glioma invasion in vitro.
      Catalogue Number516705
      Brand Family Calbiochem®
      Synonyms1,10-Phenanthroline Monohydrate
      References
      ReferencesStix, B., et al. 2001. Am. J. Pathol. 159, 561.
      Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
      Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
      Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
      Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
      Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.
      Product Information
      CAS number5144-89-8
      ATP CompetitiveN
      FormWhite to cream solid
      Hill FormulaC₁₂H₈N₂ · H₂O
      Chemical formulaC₁₂H₈N₂ · H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMetalloprotease inhibitor
      Purity≥99% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSF8437000
      Safety Information
      R PhraseR: 25-50/53

      Toxic if swallowed.
      Very toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
      S PhraseS: 45-60-61-37

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      This material and its container must be disposed of as hazardous waste.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Wear suitable gloves.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      516705-500MG 04055977198287

      Documentation

      o-Phenanthroline - CAS 5144-89-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      o-Phenanthroline - CAS 5144-89-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      516705

      Références bibliographiques

      Aperçu de la référence bibliographique
      Stix, B., et al. 2001. Am. J. Pathol. 159, 561.
      Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
      Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
      Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
      Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
      Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-August-2018 JSW
      Synonyms1,10-Phenanthroline Monohydrate
      DescriptionA metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general matrix metalloproteinase inhibitor. Forms a red chelate with Fe2+ that absorbs maximally at 510 nm. Can be used as a photometric reagent for iron.
      FormWhite to cream solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number5144-89-8
      RTECSSF8437000
      Chemical formulaC₁₂H₈N₂ · H₂O
      Structure formulaStructure formula
      Purity≥99% by titration
      SolubilityDMSO (100 mg/ml), ethanol (25 mg/ml), or H₂O (3 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 3 months at 4°C.
      Toxicity Toxic
      Merck USA index14, 7214
      ReferencesStix, B., et al. 2001. Am. J. Pathol. 159, 561.
      Bolzan, A.D., et al. 2000. Mutat. Res. 447, 221.
      Wang, Y., et al. 1999. J. Biol. Chem. 274, 33043.
      Harayama, T., et al. 1999. Jpn. J. Can. Res. 90, 942.
      Krane, S.M., et al. 1996. J. Biol. Chem. 271, 28509.
      Uhm, J.H., et al. 1996. Clin. Exp. Metastasis 14, 421.