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14-770M mTOR (1362-end) Protein, active, 100 µg

Active, N-terminal FLAG-tagged, recombinant, human mTOR, amino acids 1362-end, for use in Kinase Assays.

mTOR (1362-end) Protein, active, 100 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
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14-770M
100 µg  Also available in 10 μg size (cat#14-770) and in bulk (cat# 14-770-K).
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      Aperçu

      Replacement Information
      Description
      Catalogue Number14-770M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionmTOR (1362-end) Protein, active, 100 µg
      OverviewN-terminal FLAG-tagged, recombinant, human mTOR, amino acids 1362-end
      Alternate Names
      • FRAP1
      References
      Product Information
      Presentation16µg of enzyme in 100µl of 10mM HEPES, 50mM NaCl, 50mM β-glycerophosphate, 0.25mM sodium orthovanadate, 10mM NaF, 300µg/ml FLAGTM peptide, 20% v/v glycerol
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal FLAG-tagged, recombinant, human mTOR, amino acids 1362-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Specific Activity377Units/mg, where one unit of mTOR activity is defined as 1 nmole of phosphate incorporated into 2mg/ml mTOR substrate per minute at 30°C with a final ATP concentration of 100µM.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene.
      Gene Symbol
      • FRAP1
      • RAPT1
      • MTOR
      • FRAP
      • mTOR
      • FLJ44809
      • FRAP2
      • RAFT1
      Protein TargetmTOR (FRAP1)
      Target Sub-FamilyLipid/Atypical
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
      SIZE: 2549 amino acids; 288892 Da
      SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.
      TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.
      SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Material PackageAlso available in 10 μg size (cat#14-770) and in bulk (cat# 14-770-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-770M 04053252337680

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-770 mTOR (1362-end) Protein, active, 10 µg Prix & Disponibilité

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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases