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445865 mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem

A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Primary Target: Metabotropic glutamate receptor subtype 5 (mGluR5)
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      781652-57-1C₂₃H₁₆N₄O
      Description
      Overview

      This product has been discontinued.



      A pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
      Catalogue Number445865
      Brand Family Calbiochem®
      Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
      References
      ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
      Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.
      Product Information
      CAS number781652-57-1
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₃H₁₆N₄O
      Chemical formulaC₂₃H₁₆N₄O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMetabotropic glutamate receptor subtype 5 (mGluR5)
      Primary Target IC<sub>50</sub>EC50 = 10 nM in potentiating the response to glutamate (~300 nM) in CHO-mGluR5 cells for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      445865 0

      Documentation

      mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      445865

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
      Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.

      Brochure

      Titre
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
      DescriptionA pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number781652-57-1
      Chemical formulaC₂₃H₁₆N₄O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
      Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.