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508510 ZD 7288 - CAS 133059-99-1 - Calbiochem

A potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain.

ZD 7288 - CAS 133059-99-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288

Primary Target: HCN channel
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508510
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Tableau de caractéristiques principal

CAS #Empirical Formula
133059-99-1C₁₅H₂₁ClN₄

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      Description
      OverviewA potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508510
      Brand Family Calbiochem®
      SynonymsZeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
      References
      ReferencesWu, X., et al. 2012. Channels (Austin). 6, 438.
      Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.
      Product Information
      CAS number133059-99-1
      FormWhite solid
      Hill FormulaC₁₅H₂₁ClN₄
      Chemical formulaC₁₅H₂₁ClN₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHCN channel
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.08510.0001 04055977262032

      Documentation

      ZD 7288 - CAS 133059-99-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wu, X., et al. 2012. Channels (Austin). 6, 438.
      Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-January-2014 JSW
      SynonymsZeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
      DescriptionA potent blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na(+) currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.
      FormWhite solid
      CAS number133059-99-1
      Chemical formulaC₁₅H₂₁ClN₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWu, X., et al. 2012. Channels (Austin). 6, 438.
      Harris, N.C., and Constanti, A. 1995. J. Neurophysiol. 74, 2366.