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681725 WY-14643 - CAS 50892-23-4 - Calbiochem

One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands.

WY-14643 - CAS 50892-23-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: [4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I

Primary Target: Peroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      50892-23-4C₁₄H₁₄ClN₃O₂S
      Description
      Overview

      This product has been discontinued.



      One of the most potent peroxisome proliferator-activated receptor α (PPARα) ligands. Inhibits TNF-α induced expression of VCAM-1 in endothelial cells. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
      Catalogue Number681725
      Brand Family Calbiochem®
      Synonyms[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I
      References
      ReferencesMarx, N., et al. 1999. Circulation 99, 3125.
      Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
      Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
      Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
      Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
      Dreyer, C., et al. 1992. Cell 68, 879.
      Issemann, I., and Green, S. 1990. Nature 347, 645.
      Product Information
      CAS number50892-23-4
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₄H₁₄ClN₃O₂S
      Chemical formulaC₁₄H₁₄ClN₃O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPeroxisome proliferator-activated receptor 7alpha; (PPARα) ligands
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAG2915000
      Safety Information
      R PhraseR: 22-36/37/38-45

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause cancer.
      S PhraseS: 26-36/37/39-45-53

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      681725 0

      Documentation

      WY-14643 - CAS 50892-23-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      WY-14643 - CAS 50892-23-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      681725

      Références bibliographiques

      Aperçu de la référence bibliographique
      Marx, N., et al. 1999. Circulation 99, 3125.
      Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
      Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
      Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
      Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
      Dreyer, C., et al. 1992. Cell 68, 879.
      Issemann, I., and Green, S. 1990. Nature 347, 645.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      Synonyms[4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic Acid, PPAR Agonist I, PPARα Agonist I
      DescriptionA potent peroxisome proliferator. A hepatocarcinogen and tumor promoter. Also acts as a potent anti-hypercholesterolemic agent.
      FormWhite crystalline solid
      CAS number50892-23-4
      RTECSAG2915000
      Chemical formulaC₁₄H₁₄ClN₃O₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesMarx, N., et al. 1999. Circulation 99, 3125.
      Murakami, K., et al. 1999. Biochem. Biophys. Res. Commun. 260, 609.
      Tugwood, J.D., et al. 1996. Ann. N.Y. Acad. Sci. 804, 252.
      Keller, H., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2160.
      Keller, H., and Wahli, W. 1993. Trends Endocrinol. Metab. 4, 291.
      Dreyer, C., et al. 1992. Cell 68, 879.
      Issemann, I., and Green, S. 1990. Nature 347, 645.