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616400 Tranilast - CAS 53902-12-8 - Calbiochem

An anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis.

Tranilast - CAS 53902-12-8 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid

Primary Target: VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
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616400
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
53902-12-8C₁₈H₁₇NO₅

Prix & Disponibilité

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616400-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Inhibits VEGF- and PMA-stimulated PKC activity in retinal capillary endothelial cells without affecting the VEGF binding or VEGF receptor phosphorylation. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
      Catalogue Number616400
      Brand Family Calbiochem®
      SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
      References
      ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
      Isaji, M., et al. 1998. Life Sci. 63, PL71.
      Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
      Product Information
      CAS number53902-12-8
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₈H₁₇NO₅
      Chemical formulaC₁₈H₁₇NO₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDG8731000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      616400-10MG 04055977185683

      Documentation

      Tranilast - CAS 53902-12-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Tranilast - CAS 53902-12-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      616400

      Références bibliographiques

      Aperçu de la référence bibliographique
      Koyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
      Isaji, M., et al. 1998. Life Sci. 63, PL71.
      Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      SynonymsN-(3ʹ,4ʹ-Dimethoxycinnamoyl)anthranilic Acid
      DescriptionAn anthranilic acid analog that acts as a potent inhibitor of VEGF- and vascular permeability factor-induced angiogenesis and collagen synthesis. Also has antiallergic, anti-inflammatory, and antiproliferative properties. Induces Ca2+ mobilization in vascular smooth muscle.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number53902-12-8
      RTECSDG8731000
      Chemical formulaC₁₈H₁₇NO₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Toxicity Harmful
      Merck USA index14, 9570
      ReferencesKoyama, S., et al. 1999. Br. J. Pharmacol. 127, 537.
      Isaji, M., et al. 1998. Life Sci. 63, PL71.
      Isaji, M., et al. 1997. Br. J. Pharmacol. 122, 1061.