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504793 Tamsulosin Hydrochloride - CAS 106463-17-6 - Calbiochem

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Synonymes: (R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride

Primary Target: →1A adrenoceptor
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      106463-17-6C₂₀H₂₈N₂O₅S • HCl
      Description
      Overview

      This product has been discontinued.



      A selective α1A adrenoceptor antagonist that has preferential selectivity for the α1A adrenoceptor in the prostate versus the α1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo.
      Catalogue Number504793
      Brand Family Calbiochem®
      Synonyms(R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride
      References
      ReferencesGarcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
      Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
      Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
      Roehrborn, G., et al. 2008. J. Urol. 179, 616.
      Product Information
      CAS number106463-17-6
      FormWhite to beige powder
      Hill FormulaC₂₀H₂₈N₂O₅S • HCl
      Chemical formulaC₂₀H₂₈N₂O₅S • HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target→1A adrenoceptor
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504793 0

      Documentation

      Tamsulosin Hydrochloride - CAS 106463-17-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Garcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
      Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
      Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
      Roehrborn, G., et al. 2008. J. Urol. 179, 616.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-February-2020 JSW
      Synonyms(R)-5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide hydrochloride, Tamsulosin, α₁-Adrenoceptor Antagonist, Tamsulosin Hydrochloride
      DescriptionA selective α1A adrenoceptor antagonist that has preferential selectivity for the α1A adrenoceptor in the prostate versus the α1B adrenoceptor in the blood vessels (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Used for treatment of difficult urination, a common symptom of enlarged prostate. Has negligible effect on arterial blood pressure in vivo.
      FormWhite to beige powder
      CAS number106463-17-6
      Chemical formulaC₂₀H₂₈N₂O₅S • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from moisture
      Protect from light
      +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Sainz, J., et al. 1995. Eur. J. Pharmacol. 289, 1.
      Taguchi, K., et al. J. Pharmacol. Exp. Ther. 280, 1.
      Ohtake, A., et al. 2005. J. Pharm. Pharmacol. 58, 345.
      Roehrborn, G., et al. 2008. J. Urol. 179, 616.