Millipore Sigma Vibrant Logo

616402 TACE Substrate II, Fluorogenic

TACE Substrate II, Fluorogenic : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: TNF-α Convertase Enzyme Substrate, Fluorogenic, ADAM-17 Substrate II, Fluorogenic, MCA-PLAQAV(Dpa)RSSSR-NH₂

616402
  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A fluorogenic peptide substrate for TACE (Km = ~ 19 µM). Substrate cleavage occurs at the Ala-Val bond. Useful for screening TACE Inhibitors.
      Catalogue Number616402
      Brand Family Calbiochem®
      SynonymsTNF-α Convertase Enzyme Substrate, Fluorogenic, ADAM-17 Substrate II, Fluorogenic, MCA-PLAQAV(Dpa)RSSSR-NH₂
      References
      ReferencesPatel, I.R., et al. 1998. J. Immunol. 160, 4570.
      Van Dyk, D.E., et al. 1997. Bioorg. Med. Chem. Lett. 7, 1219.
      Product Information
      FormLiquid
      FormulationA 4 mM (7.5 mg/ml) solution in DMSO.
      Hill FormulaC₆₉H₁₀₃N₂₃O₂₄
      Chemical formulaC₆₉H₁₀₃N₂₃O₂₄
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Peptide SequenceMCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH₂[Dpa = N-3-(2,4-Dinitrophenyl)-L-2,3-diaminopropionyl]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      616402 0

      Documentation

      TACE Substrate II, Fluorogenic Certificats d'analyse

      TitreNuméro de lot
      616402

      Références bibliographiques

      Aperçu de la référence bibliographique
      Patel, I.R., et al. 1998. J. Immunol. 160, 4570.
      Van Dyk, D.E., et al. 1997. Bioorg. Med. Chem. Lett. 7, 1219.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2008 RFH
      SynonymsTNF-α Convertase Enzyme Substrate, Fluorogenic, ADAM-17 Substrate II, Fluorogenic, MCA-PLAQAV(Dpa)RSSSR-NH₂
      DescriptionA fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). Cleavage of this TACE substrate II occurs between the alanine and valine residues. Useful for the screening of TACE inhibitors. Excitation max: ~320 nm; emission max: ~395 nm.
      FormLiquid
      FormulationA 4 mM (7.5 mg/ml) solution in DMSO.
      Recommended reaction conditions50 mM Tricine buffer, pH 7.5, containing 100 mM NaCl, 10 mM CaCl2, and 1 mM ZnCl2, 10 µM TACE Substrate II, 600 nM TACE; incubate at 27°C with mechanical shaking; reaction can be quenched with 50 mM EDTA (final concentration); cleavage monitored at excitation at ~320 nm and emission at ~395 nm.
      Chemical formulaC₆₉H₁₀₃N₂₃O₂₄
      Peptide SequenceMCA-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH₂[Dpa = N-3-(2,4-Dinitrophenyl)-L-2,3-diaminopropionyl]
      Purity≥90% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesPatel, I.R., et al. 1998. J. Immunol. 160, 4570.
      Van Dyk, D.E., et al. 1997. Bioorg. Med. Chem. Lett. 7, 1219.